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CPE PPE Study 2022 – information on PPE and enrolment

Public Health England’s Healthcare Associated Infections and Antimicrobial Resistance department (PHE HCAI & AMR) are planning a point prevalence survey (PPS) into carbapenemase-producing Enterobacterales (CPE) in intensive care. The PPS will run, subject to capacity, in the first two weeks of April 2022. We will select NHS Trusts from across England at random and invite them to participate in one or several age categories of intensive care: adults, paediatrics, and neonates. Units which provide level 3 care, either exclusively or alongside other levels, will be eligible. If selected, each Trust will be asked to randomly sample up to 20 patients from their intensive care units, who are inpatients on a single day (chosen by the Trust) within the two-week study period. Trusts with fewer than 20 occupied ICU beds should include all their current inpatients. The CPE PPS will enable PHE to estimate the prevalence of CPE in intensive care in England, across adult, paediatric, and neonatal populations. It will also allow us to identify key risk factors for CPE colonisation and infection, which will inform preventive measures. You will hear from us in the next week or two if your Trust is randomly selected to participate. We will send further information and the study protocol then. Participation is voluntary but we would be grateful of your support in this important study. If you are not randomly selected, but are keen for your Trust to participate, please do get in touch at cpe.pps@phe.gov.uk we are happy for additional Trusts to be involved.
England PPS Study

England Point Prevalence Survey (PPS)

It is reported that on any given day, approximately 80 000 patients have at least one healthcare-associated infection (HAI), i.e. one in 18 patients in a European hospital (ECDC).

ECDC’s point prevalence survey (PPS) of healthcare-associated infections (HAIs) and antimicrobial use is the largest survey of its kind ever performed in Europe (with more than 1 000 hospitals in 33 countries). In England this survey was commissioned by PHE . The survey was conducted from 2011-2012. The survey confirms that HAIs represent a major public health problem. The final report was published in 2016.

One of the major findings of this report was the higher prevalence of HAI in ITU’s across Europe:

“The prevalence of HAIs varied from 4.8% (median HAI prevalence 3.9%, IQR 1.9–6.1%) in primary hospitals to 7.2% (median HAI prevalence 6.9% IQR 4.0–9.7%) in tertiary hospitals. HAI prevalence was highest in patients admitted to ICU, where 19.5% patients had at least one HAI compared with 5.2% on average for all other specialties combined.”

FICM ICCQIP:https://www.ficm.ac.uk/ICCQIP

Matching Michigan Study

‘Matching Michigan’: a 2-year stepped interventional programme to minimise…

Matching Michigan

The matching Michigan study was a four cluster, 2-year programme, run in England from April 2009 to the end of March 2011. It aimed to minimise CVC-BSI rates in adult and paediatric ICUs in England to at least the mean level (1.4 per 1000 CVC-patient days), as seen in the Michigan-Keystone project. A total of 215 out of 223 ICUs in England participated in this 2 year study, evaluating technical and non-technical (behavioural) interventions to prevent CVC-BSIs in adult and paediatric ICUs.

The study observed the mean CVC-BSI rate decrease over 20 months from 3.7 in the first cluster to 1.48 CVC-BSIs/1000 CVC-patient days (p<0.0001) for all clusters combined, and from 5.65 to 2.89 (p=0.625), in adult and paediatric units, respectively.

This surveillance project looks to continue this work on a long term basis and inform Trusts and ICUs of their CVC-BSI rates, to enable them to manage and reduce these infections. Dr Julian Bion one of the lead’s for the Matching Michigan Project, is also leading on ICCQIP surveillance project along with Professor Peter Wilson.

‘Matching Michigan’: a 2-year stepped interventional programme to minimise central venous catheter-blood stream infections in intensive care units in England
Julian Bion, Annette Richardson, Peter Hibbert, Jeanette Beer, Tracy Abrusci, Martin McCutcheon, Jane Cassidy, Jane Eddleston, Kevin Gunning, Geoff Bellingan, Mark Patten, David Harrison, THE MATCHING MICHIGAN COLLABORATION & WRITING COMMITTEE